Written in English
Ph.D.thesis of the Universityof London.
Adrenergic nerves containing the neurotransmitter norepinephrine are believed to exert inhibitory influences on pancreatic secretion. However, studies to establish these effects have been difficult because of the many diverse effects of sympathetic nerve stimulation or nonspecific effects following administration of adrenergic agents. Any agent that binds to and inhibits adrenergic receptors. Adrenergic Neuron Blockers and Guanethidine. Pharmacology 10, Views. Once impulse arrives, Any dose cannot be adjusted before this time. Sympathoplegia persists even after cessation of therapy for some time. When taken orally, only fall in blood pressure occurs. Actions depend on the route of administration and how rapidly given: 1. a·gent (ā'jent), 1. An active force or substance capable of producing an effect. For agents not listed here, see the specific name. 2. In disease, a factor such as a microorganism, chemical substance, or a form of radiation, the presence or absence of which (as in deficiency diseases) results in disease or in more advanced form of disease. [L. ago.
Responses to intravenous dimethylphenylpiperazinium are also increased and the results suggest that even large daily doses of adrenergic neurone blocking agents do not appreciably impair the. to adrenaline and noradrenaline produced by adrenergic neurone blocking agents but fit the hypothesis that "tolerance" to adrenergic neurone blockade in any system is related to the rise in responsiveness to the adrenergic transmitter. Some investigations of the Cited by: A compound that selectively blocks or inhibits responses to sympathetic adrenergic nerve activity (sympatholytic agent) and to epinephrine, norepinephrine, and other adrenergic amines (adrenolytic agent); two distinct classes exist, alpha- and beta-adrenergic receptor blocking agents. Beta adrenergic blocking agents: A class of drugs, also called beta blockers, that block beta-adrenergic substances such as adrenaline (epinephrine), a key agent in the "sympathetic" portion of the autonomic (involuntary) nervous system. By blocking the action of the sympathetic nervous system on the heart, these agents relieve stress on the heart.. They slow the heart beat, lessen the force.
May 28, · Noradrenaline is the main neurotransmitter of the sympathetic nervous system, so adrenergic neuron blocker drugs act like other ANTISYMPATHETIC AGENTS to cause an overall fall in blood pressure. Their therapeutic action normally takes some weeks to develop, and their mechanisms of action result in some initial release of noradrenaline. Abbs, E.T., Dodd, M.G.: The relation between the adrenergic neurone-blocking and noradrenaline-depleting actions of some guanidine derivatives. Br. Further studies on the adrenergic neurone blocking activity of some β-adrenoceptor antagonists and guanethidine. The action of adrenergic neurone blocking agents and other drugs on the Cited by: 6. adrenergic neurone blocking drugs,12 and the serious withdrawal phenomena found with clonidine13 are not frequent manifestations of beta-blocker therapy. Once-Daily Treatment. Almost one-third of the patients on antihypertensive treatment fail to take exactly . Bretylium abolishes neurotransmitter release without necessarily abolishing the nerve terminal action potential in sympathetic terminals Article in British Journal of Pharmacology (4)